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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Circ Res. 2013 Sep 6;113(10):1117–1127. doi: 10.1161/CIRCRESAHA.113.301306

Figure 1. MicroRNA (miR)-663 is significantly downregulated in proliferating vascular smooth muscle cells (VSMCs).

Figure 1

A, Platelet-derived growth factor-BB (PDGF-BB; 20 ng/mL) caused a time-dependent decrease in miR-663 expression in human aortic VSMCs, as determined by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) (n=4). *P<0.05 compared with 0 h group. B, PDGF-BB caused a dose-dependent decrease in miR-663 expression in human aortic VSMCs at 24 h after PDGF treatment, as determined by qRT-PCR (n=4). *P<0.05 compared with that in VSMCs without PDGF-BB. C, In situ hybridization (violet) shows miR-663 was significantly decreased in PDGF-BB–stimulated (20 ng/mL) VSMCs. D, Serum (5%) caused a time-dependent decrease in miR-663 expression in human aortic VSMCs, as demonstrated by qRT-PCR (n=4). *P<0.05 compared with that without 5% fetal bovine serum treatment.