Table 2:
Association between GST genotype profile and the development of metabolic syndrome
| Locus | Genotype | Patient (n=51) (%) | Control (n=50) (%) | Odds ratio (95 % CI) | P-value |
|---|---|---|---|---|---|
| GSTT1 | Present | 37 (72.5) | 14 (28) | 1.00 (Ref) | |
| null | 14 (27.5) | 38 (72) | 1.01 (0.41–2.40) | 0.98 | |
| GSTM1 | Present | 25 (49) | 27 (54) | 1.00 (Ref) | |
| null | 26 (51) | 23 (46) | 1.25 (0.55–2.84) | 0.59 | |
| GSTP1 | I/I | 9 (17.6) | 19 (38) | 1.00 (Ref) | |
| I/V | 21 (41.2) | 15 (30) | 0.35 (0.12–0.98) | 0.047 | |
| V/V | 21 (41.2) | 16 (32) | 0.34 (0.12–0.97) | 0.044 | |
| Two loci GSTT1 and GSTM1 | Both present | 19 (37.3) | 21 (42) | 1.00 (Ref) | |
| Either null | 24 (47.1) | 21 (42) | 0.90 (0.28–2.88) | 0.86 | |
| Both null | 8 (15.7) | 8 (16) | 0.79 (0.33–1.8) | 0.59 | |
| GSTT1 (+/+) and GSTP1 | T1 (+/+) and I/I | 5 (13.5) | 14 (38.9) | 1.00 (Ref) | |
| T1 (+/+) and I/V | 16 (43.2) | 11 (30.6) | 0.246 (0.06–0.88) | 0.031 | |
| T1 (+/+) and V/V | 16 (43.2) | 11 (30.6) | 0.246 (0.06–0.88) | 0.031 | |
| GSTT1 (−/−) and GSTP1 | T1 (−/−) and I/I | 4 (28.6) | 5 (35. 7) | 1.00 (Ref) | |
| T1 (−/−) and I/V | 5 (35. 7) | 4 (28.6) | 0.8 (0.13–4.8) | 0.809 | |
| T1 (−/−) and V/V | 5 (35. 7) | 5 (35. 7) | 0.64 (0.1–4.1) | 0.63 | |
| GSTM1 (+/+) and GSTP1 | M1 (+/+) and I/I | 6 (24) | 8 (29.6) | 1.00 (Ref) | |
| M1 (+/+) and I/V | 7 (28) | 8 (29.6) | 0.68 (0.18–2.6) | 0.58 | |
| M1 (+/+) and V/V | 12 (48) | 11 (40.7) | 0.85 (0.19–3.7) | 0.85 | |
| GSTM1 (−/−) and GSTP1 | M1 (−/−) and I/I | 3 (11.5) | 11 (47.8) | 1.00 (Ref) | |
| M1 (−/−) and I/V | 14 (53.8) | 7 (30.4) | 0.15 (0.02–0.81) | 0.028 | |
| M1 (−/−) and V/V | 9 (34.6) | 5 (21.7) | 0.13 (0.02–0.65) | 0.013 | |
| Three loci M1 (+/+), T1 (+/+) and GSTP1 | M1 (+/+), T1 (+/+) and I/I | 4 (21.1) | 7 (33.3) | 1.00 (Ref) | |
| M1 (+/+), T1 (+/+) and I/V | 5 (26.3) | 6 (28.6) | 0.45 (0.09–2.1) | 0.319 | |
| M1 (−/−), T1 (+/+) and V/V | 10 (52.6) | 8 (38.1) | 0.68 (0.12–3.7) | 0.66 | |
| M1 (−/−), T1 (+/+) and GSTP1 | M1 (−/−), T1 (+/+) and I/I | 1 (5.6) | 7 (46.7) | 1.00 (Ref) | |
| M1 (−/−), T1 (+/+) and I/V | 11 (61.1) | 5 (33.3) | 0.071 (0.006–0.8) | 0.039 | |
| M1 (−/−), T1 (+/+) and V/V | 6 (33.3) | 3 (20) | 0.065 (0.006–0.6) | 0.022 | |
| M1 (+/+), T1 (−/−) and GSTP1 | M1 (+/+), T1 (−/−) and I/I | 2 (33.3) | 1 (16.7) | 1.00 (Ref) | |
| M1 (+/+), T1 (−/−) and I/V | 2 (33.3) | 2 (33.3) | 3 (0.15–59) | 0.472 | |
| M1 (+/+), T1 (−/−) and V/V | 2 (33.3) | 3 (50) | 2 (0.9–44) | 0.661 | |
| M1 (−/−), T1 (−/−) and GSTP1 | M1 (−/−), T1 (−/−) and I/I | 2 (25) | 4 (50) | 1.00 (Ref) | |
| M1 (−/−), T1 (−/−) and I/V | 3 (37.5) | 2 (25) | 0.33 (0.02–3.9) | 0.38 | |
| M1 (−/−), T1 (−/−) and V/V | 3 (37.5) | 2 (25) | 0.33 (0.02–3.9) | 0.38 |
n: number of sample