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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Cell Host Microbe. 2015 Jul 8;18(1):27–37. doi: 10.1016/j.chom.2015.06.011

Figure 5. Selective loss of ILC3s or ILC3 effector molecules reveals their limited role in recovery following acute C. difficile infection.

Figure 5

(A) Weight loss and (B) survival of RorcHET or Rorc KO mice following CDI. Combination of 3 independent experiments (n=10-11). (C-G) C57BL/6 and Il22−/− mice were infected with C. difficile spores and assessed for (C) weight loss and (D) survival. Weight loss curve is representative of 4 independent experiments. Survival curve is a combination of 4 experiments (n=21-22). (E) C. difficile burden and (F) toxin levels in the cecal content at day 3 post-infection. (G) Fold induction of Reg3g, Ifng, and Nos2 in the colon of day 3 infected C57BL/6 and Il22−/− mice relative to uninfected C57BL/6 mice and normalized to Hprt (n=7-8). (H) Weight loss and (I) survival of Rag1−/− or Rag1−/− mice treated with anti-IL-17a neutralizing antibody (n=8). (J) Survival of Rag1−/− or Rag.Il17 dKO− mice (n=7-9). *p<0.05, **p<0.01. Data shown are mean ± SEM. See also Figure S5.