Figure 2.

Similarities in the distribution of alterations in functional activity in response to the presentation of cues associated with cocaine self-administration (left side of each brain image) and post-cocaine self-administration (right side of each brain image). Shown are autoradiograms of 2-[¹⁴C]deoxyglucose uptake in coronal sections at the level of the A, prefrontal cortex, B, striatum, and C, thalamus of the rhesus monkey. Areas shaded in red (left) depict those regions in which significant increases in rate of glucose utilization were measured following the presentation of cocaine-associated stimuli. Areas shaded in blue (right) depict those areas of significant alterations in rates of glucose utilization in response to cocaine self-administration in its earliest stages (5 days exposure). Note that in both cases, effects were bilateral, however for the purposes of comparison they are depicted on one hemisphere.