Table 2.
WB | Serum | ||||
---|---|---|---|---|---|
Metabolite | KEGGa ID | Concentration (μM)b | p value | FDRc (%) | |
Choline | C00114 | 13.6, 4.3 | 5.2, 5.4 | 0.0001 | 0.14 |
Creatine | C00300 | 167.2, 60.3 | 19.2, 10.9 | 0.0001 | 0.14 |
Glutamate | C00217 | 149.7, 27.3 | 45.2, 33.2 | 0.0001 | 0.14 |
Glycine | C00037 | 254.7, 75.8 | 139.4, 38.2 | 0.0001 | 0.14 |
Leucine | C00123/C01570 | 77.8, 10.5 | 37.9, 15.4 | 0.0001 | 0.14 |
Ornithine | C00077/C00515 | 58,8, 19.0 | 30.4, 17.6 | 0.0001 | 0.14 |
Proline | C00148/C00763 | 121.0, 46.4 | 57.5, 27.8 | 0.0001 | 0.14 |
Serine | C00065/C007740 | 115.3, 63.4 | 69.1, 29.8 | 0.0001 | 0.14 |
Taurine | C00245 | 169.3, 48.5 | 79.8, 43.2 | 0.0001 | 0.14 |
Creatine phosphate | C02305 | 19.8, 10.2 | 12.0, 5.2 | 0.0004 | 0.14 |
Isoleucine | C00407 | 39.0,8.2 | 24,4, 13.1 | 0.0013 | 0.42 |
Methionine | C00073 | 24.3, 6.1 | 16.0, 8.5 | 0.0015 | 0.44 |
Phenylalanine | C00079 | 42.7, 11.8 | 32.2, 13.5 | 0.0021 | 0.56 |
Betaine | C00719 | 39.2, 21.0 | 20.7, 8.8 | 0.0028 | 0.66 |
Alanine | C00041/C00133 | 255.8, 77.2 | 208.4, 72.4 | 0.0029 | 0.66 |
Glycerol | C00116 | 46.4, 18.6 | 85.8, 131.5 | 0.0031 | 0.66 |
Valine | C00183 | 132.8, 27.8 | 100.2, 38.6 | 0.0230 | 4.50 |
2-Hydroxybutyrate | C05984 | 18.5, 8.0 | 11.0, 15.3 | 0.0239 | 4.50 |
Tyrosine | C00082 | 45.3, 13.6 | 36.2, 15.1 | 0.0342 | 6.08 |
Ethanol | C00469 | 29.7, 21.2 | 39.2, 31.7 | 0.0463 | 7.80 |
Glucose | C00031 | 2341.3, 636.4 | 2124.2, 428.1 | 0.0490 | 7.84 |
Acetate | C00033 | 75.2, 44.3 | 43.6, 19.8 | 0.1027 | 15.27 |
Threonine | C00188 | 75.8, 42.2 | 96.2, 36.5 | 0.1050 | 15.27 |
Glutamine | C00819/C00064 | 304.3, 73.3 | 257.2, 48.4 | 0.1101 | 15.32 |
Carnitine | C00318 | 20.9, 3.2 | 18.0, 5.4 | 0.1203 | 16.04 |
Lactate | C00186/C00256 | 1142.0, 741.0 | 973.6, 630.0 | 0.2341 | 29.96 |
Tryptophan | C00078/C00525 | 26.5, 6.6 | 22.7, 9.8 | 0.3058 | 37.64 |
Arginine | C00062/C00792 | 54.0, 22.8 | 56.2, 26.4 | 0.3982 | 47.19 |
Lysine | C00047/C00739 | 89.6, 29.3 | 89.3, 29.8 | 0.4538 | 51.86 |
3-Hydroxybutyrate | C01089 | 31.5, 31.9 | 24.5, 28.0 | 0.5377 | 59.33 |
Creatinine | C00791 | 29.6, 8.9 | 28.4, 10.4 | 0.7736 | 82.52 |
Citrate | C00158 | 30.1, 11.1 | 29.9, 8.4 | 0.9113 | 94.07 |
Kyoto Encyclopedia Genes and Genomes (KEGG) identification (ID) numbers (http://www.genome.jp/kegg/)
concentration data are median, interquartile range of 19 and 20 healthy volunteers for whole blood (WB) and serum, respectively
false discovery rate