(a) Animal studies

First author	Year	Dose	Sample	Duration (w)	Study design	Outcome measure	Results
Nyby [84]	2005	Diet enriched with 60% fructose and 4.4% n-3 PUFA versus diet with 60% fructose or control diet	Hyperinsulinemic rats	8	AES-PG	EDD, oxidative stress	Improve EDD and oxidative stress
Matsumoto [88]	2009	300 mg/kg/day EPA versus control diet	Diabetic rats	4	AES-PC	EDD	Improve EDD
Zhang [83]	2013	Diet enriched with ALA 500 mg/kg/day versus control diet	Type 2 diabetic rats	5	AES-PC	EDD, oxidative stress	Improve EDD and oxidative stress
Gortan Cappellari [82]	2013	800 mg/kg/day by gavage versus control diet	Ovariectomized rats	8	AES-PC	EDD, oxidative stress	Improve EDD and oxidative stress