A. Domain architecture of netrin-1, depicting a laminin-like domain (LN), three epidermal growth like repeats (E1 - E3), and the C-terminal domain (NTR). B. The domain architecture of DCC, depicting its four immunoglobulin domains (Ig 1-4), six fibronectin type-3 (FN1 - FN6) domains, three P motifs (P1 - P3), and their orientation relative to the plasma membrane. C. The domain architecture of UNC5-A, depicting its two immunoglobulin domains (Ig1 - Ig2), two thrombospondin type I repeat domains (TS1 -TS2), the ZU-5 domain (as initially found in ZO-1 and UNC5), the UPA domain (which is conserved in UNC5, PIDD, and ankyrins) and the DD domain (death domain).