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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Prog Biophys Mol Biol. 2015 Apr 14;118(3):153–160. doi: 10.1016/j.pbiomolbio.2015.04.001

Figure 1. The domain architecture of netrin-1 and its receptors DCC and UNC5.

Figure 1

A. Domain architecture of netrin-1, depicting a laminin-like domain (LN), three epidermal growth like repeats (E1 - E3), and the C-terminal domain (NTR). B. The domain architecture of DCC, depicting its four immunoglobulin domains (Ig 1-4), six fibronectin type-3 (FN1 - FN6) domains, three P motifs (P1 - P3), and their orientation relative to the plasma membrane. C. The domain architecture of UNC5-A, depicting its two immunoglobulin domains (Ig1 - Ig2), two thrombospondin type I repeat domains (TS1 -TS2), the ZU-5 domain (as initially found in ZO-1 and UNC5), the UPA domain (which is conserved in UNC5, PIDD, and ankyrins) and the DD domain (death domain).