Skip to main content
. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Jul 5;232(18):3455–3467. doi: 10.1007/s00213-015-4000-4

Figure 3. Time spent immobile in the TST and FST after physostigmine administration and its reversal by lithium in the FST.

Figure 3

Each dose of physostigmine increased immobility times compared to saline in the TST (a). Both 0.03 and 0.1 mg/kg increased immobility times compared to saline in the FST, but 0.01 mg/kg had no effect (b). In another group of mice, physostigmine (Phy; 0.03 mg/kg) increased immobility times compared to saline (Sal) in the vehicle-treated mice (Veh), but after a more focused re-analysis this physostigmine-induced immobility was not observed in the mice treated with lithium 600 mg/l (c). Data are presented as mean + S.E.M. n = 10–12 animals per group. ** p<0.01 and *** p<0.001 when compared to saline and ^^^ p<0.001 when compared to vehicle.