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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Jul 5;232(18):3455–3467. doi: 10.1007/s00213-015-4000-4

Figure 5. Effects of physostigmine on sensorimotor gating of the acoustic startle response of mice.

Figure 5

The highest dose of physostigmine (0.3 mg/kg) increased PPI compared to saline (Sal) whereas 0.03 mg/kg only tended to increase PPI at the lowest prepulse (a). Physostigmine had no effect on overall amplitude of the startle response (b). When split by ISI, 0.3 mg/kg physostigmine increased PPI at ISI 100 (c). All mice exhibited habituation over time, without effect of physostigmine treatment (d). No difference between drug and saline was observed when no stimulus was presented (e). Data are presented as mean + S.E.M. n = 10 animals per group. ** p<0.01 when compared to saline.