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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Jul 5;232(18):3455–3467. doi: 10.1007/s00213-015-4000-4

Figure 7. Chronic lithium-induced attenuation of DAT blockade-induced mania-like exploratory behavior in the BPM.

Figure 7

GBR12909 significantly increased activity as measured by transitions in both groups although only in vehicle- but not chronic-lithium treated mice in post hoc tests (a). There were no effects on center entries (b). GBR12909 induced hyper-exploration as measured by increased holepoking (c) and rearing (d) overall, but not in lithium-treated mice after post hoc assessment. Treatment with GBR12909 resulted in more linear patterns of movement as deduced from lower spatial d overall in both vehicle- and lithium-treated mice (e). Data are presented as mean + S.E.M. n ≈ 12 animals per group. ** p<0.05 and *** p<0.01 when compared to saline.