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. Author manuscript; available in PMC: 2016 Aug 13.
Published in final edited form as: Cell. 2015 Jul 30;162(4):751–765. doi: 10.1016/j.cell.2015.07.009

Figure 2. RAG1 and RAG2 bind to thousands of sites in the lymphocyte genome.

Figure 2

(A) ChIP-seq for RAG1, RAG2, and H3K4me3 are shown for a region of chromosome 6 in mouse thymocytes (same color coding as in Figure 1). (B) Overlap and (C) correlation between RAG2 and H3K4me3 peaks. (D) Overlap and (E) correlation between RAG1 and H3K4me3 peaks. (F) Overlap and (G) correlation between RAG1 and RAG2 peaks. Boxplots in (D) and (F) show the H3K4me3 and RAG2 RPKM (reads per kb per million mapped reads), respectively, in sections “B” and “C” of the corresponding Venn diagrams. (H) ChIP-seq for RAG1, RAG2, and H3K4me3 are shown for a selected region of chromosome 5 in mouse pre-B cells. (I) Venn diagrams show the overlap between RAG1 and H3K4me3, and between RAG1 and RAG2 in pre-B cells. The sum of H3K4me3 peaks is not equal between (B) and (D) because one RAG peak can overlap with more than one H3K4me3 peak and vice versa. See also Figure S2 and Table S1.