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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Clin Cancer Res. 2015 May 8;21(16):3750–3758. doi: 10.1158/1078-0432.CCR-14-2650

Figure 3. Pathway analysis identifies over-representation of metabolic gene sets in myxopapillary ependymoma.

Figure 3

(A) Cytoscape enrichment map of significant genesets distinguishing Grade II versus myxopapillary spinal ependymomas identified by Gene Set Enrichment Analysis (GSEA) and visualized in Cytoscape. A statistical significance cutoff of p < 0.01 and FDR < 0.25 was used for the pathway analysis

(B) Donut plot demonstrating significant over-representation of pathways and biological processes in involving hypoxia signaling and cellular metabolism in myxopapillary spinal ependymoma

(C) Single sample GSEA demonstrating subgroup-specific over-representation of pathways and biological processes involving cellular metabolism and hypoxia signaling. Bar graph of the ages of patients is shown in the lower panel.