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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2015 Jun 4;232(18):3309–3318. doi: 10.1007/s00213-015-3983-1

Table 1.

Expected additive ED50 values (Zadd), actual (experimentally determined) ED50 values (Zmix) and, and the ratio of expected/actual ED50 values for drug combinations for antinociception in rats.

Combination Relative dose (ratio) Zadd (95% CL) Zmix (95% CL) Ratio Zadd/Zmix
OXY:2-BFI
1:3 4.10 (3.42, 4.78) 4.04 (3.01, 5.29) 1.01
1:1 2.92 (2.47, 3.37) 2.83 (1.63, 4.92) 1.03
3:1 1.74 (1.51, 1.97) 1.18 (0.95, 1.46) 1.47
OXY:phenyzoline
1:3 23.85 (21.25, 26.79) 4.50 (3.76, 5.27)* 5.30
1:1 15.90 (14.43, 17.53) 5.65 (4.87, 6.54)* 2.81
3:1 8.63 (8.04, 9.22) 1.18 (0.94, 1.46)* 4.26
*

The 95% CL of Zmix did not overlap with the 95% CL of Zadd. OXY, oxycodone.