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Quantification of the effects of PI(4,5)P2 and PI(4)P in excised inside-out patches, from reference [15] with permission. The vertical dashed line shows 1% which we assume corresponds to cellular levels of both PI(4,5)P2 and PI(4)P. The dashed curve fit to the PI(4)P data shows theoretical PI(4)P dose response corrected for the more efficient incorporation of PI(4)P into biological membranes due to its higher lipophilicity compared to PI(4,5)P2, see [15] for details.
