Fig. 2.

Denervation lowers mitochondrial content and reduces expression of cytochrome c oxidase (COX) subunits in isolated mitochondria. A: TA COX activity in response 8 h, 16 h, 24 h, 3 days, and 7 days of denervation (n = 5 per time point). B–D: representative Western blots of mitochondrial DNA-encoded proteins COX I (B) and COX II (C), as well as the nuclear DNA-encoded protein COX IV (D) in isolated subsarcolemmal mitochondria from sham-operated (S) or denervated (D) muscle (n = 4 per time point for all experiments) *P < 0.05 vs. sham at the same time point. Values are means ± SE.