Table 6.
Single-base mutations and sensitivity to 4 anti-viral drugs
| Mutations | Lamivudine/telbivudine | Entecavir | Mutations | Adefovir | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||||
| Resistant (n=28) | Sensitive (n=43) | P | Resistant (n=10) | Sensitive (n=61) | P | Resistant (n=7) | Sensitive (n=64) | P | ||||
| L180M | No | 18 | 43 | 0.000 | 5 | 56 | 0.002 | A181T | No | 5 | 64 | 0.008 |
| Yes | 10 | 0 | 5 | 5 | Yes | 2 | 0 | |||||
| M204I | No | 5 | 43 | 0.000 | 3 | 45 | 0.017 | N236T | No | 5 | 64 | 0.008 |
| Yes | 23 | 0 | 7 | 16 | Yes | 2 | 0 | |||||
| M204V | No | 24 | 43 | 0.043 | 7 | 60 | 0.008 | N/H238T | No | 5 | 64 | 0.008 |
| Yes | 4 | 0 | 3 | 1 | Yes | 2 | 0 | |||||
| V173L | No | 25 | 43 | 0.112 | 8 | 60 | 0.050 | |||||
| Yes | 3 | 0 | 2 | 1 | ||||||||