Table 3.
Selected endothelial and coagulation variables in healthy subjects and patients with chronic thromboembolic pulmonary hypertension (CTEPH)
| Parameter | Healthy subjects | CTEPH | P value |
|---|---|---|---|
| vWF:Ag (IU dL-1) | 116.5 (94.1-168.5) | 199.5 (181.1-200) | <0.0001 |
| vWF:Ac (%) | 115.5 (87.0-135.9) | 199.8 (173.8-199.8) | <0.0001 |
| Factor VIII (%) | 123.3 (100.4-199.2) | 171.6 (141.7-199.2) | <0.0001 |
| Factor XII (%) | 115.7 (95.7-126.3) | 102.2 (87.0-121.8) | NS |
| PAI-1 (U mL-1) | 2.22 (1.01-2.2) | 2.44 (1.43-3.64) | 0.0327 |
| Fibrinogen (g L-1) | 3.3 (2.6-4.9) | 3.7 (3.2-5.3) | <0.0001 |
| AT III (%) | 99.6 (92.1-107.3) | 97.8 (83.3-108) | NS |
| D-dimers (mg L-1) | 0.24 (0.19-0.38) | 0.29 (0.18-0.7) | NS |
| ACLA (U mL-1) | 0.88 (0.49-1.56) | 0.699 (0.34-1.67) | NS |
| Anti-ß2-GP (U mL-1) | 0.47 (0.18-0.99) | 0.73 (0.25-1.84) | NS |
vWF: Ag-von Willebrand factor antigen, vWF: Ac-von Willebrand factor activity, PAI-1: plasminogen activator inhibitor type 1, AT III: antithrombin III, ACLA: anti-cardiolipin antibodies, anti-ß2-GP: anti-ß2-glycoprotein. Data are shown as median and interquartile range. Comparisons between healthy subjects and CTEPH patients are analysed by the Mann-Whitney U-test. NS-non-significant values.