Figure 1.

Viability in lovastatin-treated cells was evaluated using the MTT assay. Cells were incubated with lovastatin (1 to 4 μM) (A) and with 2 μM lovastatin for 6 to 48 h (B) and 6-OHDA (100 μM) for 24 h (C). Lovastatin protected MICROGLIA cells against 6-OHDA neurotoxicity. MTT value in 6-OHDA treated group significantly reduced compared with controls (*P<0.001, 6-OHDA vs solvent controls), but lovastatin partially reversed this reduction (#P<0.001, 6-OHDA vs 6-OHDA + lovastatin). The results are displayed as the percentages of the control samples. The data are presented as the means ± S.E.M. (n=9) for three independent experiments.