Table 7.
Studies regarding the prognostic significance of the presence of multiple foci in breast carcinoma (MFMC vs. UF)
| Authors | Survival indicators |
|---|---|
| Worse prognosis | |
| Egan, 1982 [15] | Mortality ↑ |
| Dabakuyo, 2008 [16] | Mortality ↑ |
| 5 and 10-year survival ↓ | |
| Yerushalmi, 2009 [9] | Survival rate slightly ↓ |
| Boyages, 2010 [17] | Mortality rate ↑ |
| 5 and 10-year survival ↓ | |
| Weissenbacher, 2010 [4] | Mean survival ↑ |
| ↑ Local recurrence rate | |
| ↑ rate of distant metastases | |
| Tot, 2011 [5] | ↑ risk of death due to breast carcinoma |
| Ustaalioglu, 2012 [20] | ↓ Disease free survival |
| Wolters, 2013 [28] | ↓ Recurrence free survival |
| Pekar, 2013 [29] | ↓ Breast Cancer Specific Survival |
| No influence on prognosis (no statistically significant differences between compared groups) | |
| Vlastos, 2000 [30] | Breast Cancer Specific Survival at 10 years |
| Disease-Free Survival | |
| Middleton, 2002 [31] | Disease-Free Survival at 5 and 10 years |
| Oh, 2006 [32] | Overal Survival at 5 years |
| Litton, 2007 [19] | Overal Survival, Relapse-Free Survival |
| Joergensen, 2008 [11] | Overal Survival |
| Cabioglu, 2009 [33] | Disease-Free Survival at 5 years |
| Rezo, 2011 [7] | Overal Survival, Progression Free Survival |
| Lynch, 2012 [6] | Relapse-Free Survival, Breast Cancer Specific Survival-worse prognosis at 5 years (only in UVA, not in MVA-other factors are associated with ↓ survival rates |
Abbreviations: UVA - univariate analysis, MVA - multivariate analysis.