| Country |
Netherlands |
Netherlands |
Norway |
United Kingdom |
| Type |
A three-generation population based cohort study |
Birth cohort study |
Cross-sectional survey, with possibility for follow-up |
Tissue bank with residual tumor samples |
| Participants |
Aim is to include 165 000 participants, of which 15 000 children 0–18 years. Official number will follow in 2014. Children included between 2010 and 2013 |
Baseline consists of 3963 children born between 1996 and 1997 |
8677 adolescents (13–19 years) included between 2006 and 2008 |
Patients from the John Radcliffe hospital with a suspected diagnosis of a pediatric-type solid cancer. The cooperation started in 2009. Estimation: 10–30 patients per year provide consent |
| Research protocol |
Questionnaire parent, questionnaire children ≥13 years, clinical tests children ≥8 years. Follow- up every 5 years |
Part 1: Research aimed at mite allergy and asthma. Children followed up to 8 years with questionnaires for parents and clinical tests in subgroups at 1, 4 and 8. Residual blood from the newborn screening was used. Part 2: Extension of follow-up to 16 years. Research goal broadened to chronic diseases. Clinical tests (at 11/12 years and 15/16 years) and questionnaires parents and children |
Questionnaires, clinical tests and short interview at school. Phase 2 studies in subgroups: physical fitness, acne, sight or social anxiety |
Residual tissue (from a diagnostic or therapeutic sampling procedure) is stored in the tissue bank. Blood sample taken during routine blood tests |
| Biological material |
Blood and urine samples |
Blood samples, nasal epithelial cells, DNA swabs |
Buccal swabs |
Tumor tissue and blood samples |
| Inclusion |
Through parents who participate in LifeLines |
Through pregnant women |
Through schools |
Through hospital staff |
