Table 2. Overview of genotypic data obtained by next-generation sequencing.

	Total	Familial	Sporadic	Congenital onset	Early or late childhood onset	Adolescent or adult onset
Validation cohort	25	10	15	10	9	6
Patients with pathogenic mutations in an SRNS/FSGS gene	23	9	14	9	8	6
Patients with mutations in an SRNS/FSGS gene and COL4A3	2	1	1	1	1	0
Patients with no pathogenic mutations found	0	0	0	0	0	0
Discovery cohort	25	15	10	5	12	8
Patients with pathogenic mutations in an SRNS/FSGS gene	9	4	5	5	2	2
Patients with mutations in an SRNS/FSGS gene and COL4A3	1	1	0	0	0	1
Patients with no pathogenic mutations found	15	10	5	0	10	5

Abbreviations: FSGS, focal segmental glomerulosclerosis; SRNS, steroid-resistant nephrotic syndrome. Onset was classified as follows: congenital, 0–3 months; early childhood, 4 months to 5 years; late childhood, 6–12 years; adolescent, 13–18 years; adult, >18 years.