Table 1.
Individual menthol pharmacokinetic parameters
| Participant | Menthol dose (mg/kg) | Cmax (ng/mL) | Cmax (ng/mL per mg/kg dose) | Tmax (h) | Tlag (h) | AUClast (ng/mL×h per mg/kg dose) | AUCtot (ng/mL×h per mg/kg dose) | MRT (h) |
|---|---|---|---|---|---|---|---|---|
| MentPK-01 | 1.4 | 628 | 445.1 | 2.5 | 1.5 | 2941.1 | 3199.2 | 7.0 |
| MentPK-02 | 1.5 | 474 | 325.0 | 6 | 1 | 2045.6 | 2245.9 | 7.5 |
| MentPK 03 | 2.0 | 936 | 470.5 | 4 | 2 | 1951.4 | 2137.1 | 6.4 |
| MentPK 04 | 3.1 | 1056 | 342.1 | 8 | 4 | 1198.4 | 1350.5 | 9.1 |
| MentPK 05 | 1.9 | 637 | 332.8 | 3 | 1.5 | 2107.2 | 2434.8 | 7.4 |
| MentPK 06 | 1.8 | 458 | 255.5 | 8 | 2 | 1464.1 | 1879.5 | 9.4 |
AUC, area under the plasma concentration versus time curve; Cmax, apparent peak plasma concentration; MRT, mean residence time; PK, pharmacokinetic; Tlag, apparent lag time between PO administration and appearance of menthol in plasma; Tmax, time of Cmax.