Table 1.

Top 10 most significantly enriched gene sets in the cPGI₂-up-regulated gene fraction following 8 days of progenitor differentiation.

Gene set namea	Size	Enrichment scoreb	FDR q-value
KEGG_PARKINSONS_DISEASEc	87	0.77	<0.0001
KEGG_OXIDATIVE_PHOSPHORYLATION	89	0.77	<0.0001
KEGG_HUNTINGTONS_DISEASEc	129	0.67	<0.0001
KEGG_PEROXISOME	57	0.74	<0.0001
KEGG_ALZHEIMERS_DISEASEc	121	0.64	<0.0001
KEGG_CITRATE_CYCLE_TCA_CYCLE	25	0.82	<0.0001
KEGG_FATTY_ACID_METABOLISM	35	0.72	0.0001
KEGG_PPAR_SIGNALING_PATHWAY	54	0.67	0.0001
KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	40	0.65	0.001
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM	22	0.72	0.0026

^aLin⁻CD29⁺CD34⁺Sca-1⁺ cells were cultured in adipogenic media ± cPGI₂ for 8 days. RNA expression profiling was performed with Illumina beadchip arrays (n = 3). Global expression profiles (cPGI₂ vs. Control) were subjected to gene set enrichment analysis (GSEA) with the KEGG pathway gene set collection. Gene sets were ranked by the False Discovery Rate (FDR) q-value reflecting significance.

^bMaximum of the corresponding enrichment score curve.

^cThe indicated gene sets are overlapping >50% with the KEGG_OXIDATIVE_PHOSPHORYLATION gene set.