Figure 4.

Demonstration of the simulation scheme. Phenotype distributions were plotted to associate with the genotypes by two interacting SNPs, as denoted in the parentheses on top of each plot. SNPs may take values of 0, 1, and 2 or AA, Aa, and aa. For this particular dataset, the MAF was set to 0.200. On the bottom of each plot, the penetrance value for this particular model is given, which is taken from [21]. Inside each plot, the number of samples generated to satisfy the simulation constraint is given. The vertical dotted lines are for the mean values of the high- and low-risk groups. By constraint, the line on the left is for the low-risk group.