Figure 12. Influence of intra-ventral tegmental area (VTA) injection of the presynaptic GABAB receptor antagonist CGP36216 on intra-VTA injected morphine-induced conditioned place preference (CPP) in rats.
(A) Schematic representations of injection cannula tips in the VTA of rats used in data analyses. Numbers indicate coordinates relative to bregma. (B) A schematic of the experimental design for CPP and administration of drugs. (C) Influence of the presynaptic GABAB receptor antagonist CGP36216 on morphine-induced CPP in rats. Averaged CPP score of preconditioning and postconditioning in different groups (n = 6 rats in the every group; *p < 0.05, intra-VTA injection of morphine group compared with intra-VTA injection of saline group, #p < 0.05, intra-VTA injection of morphine plus CGP36216 group compared with intra-VTA injection of morphine group). Data are shown as the mean ±s.e.m.