Figure 8. Effect of the GABAB receptor antagonist CGP54626 and the GABAA receptor antagonist PTX on the frequency of sEPSCs of VTA-DA neurons in rats.
(A) Effect of the GABAB receptor antagonist CGP54626 on the frequency of sEPSCs in VTA-DA neurons. Left panel: typical current traces of sEPSCs before and after CGP54626 (2 μM). Middle panel: typical time course of the frequency of sEPSCs in DA neurons before and after CGP54626 (2 μM). Right panel: average frequency of sEPSCs before and after CGP54626 (2 μM) (n = 6 cells from four rats, p < 0.05, compared to control before CGP54626). (B) Effect of the GABAA receptor antagonist PTX on the frequency of sEPSCs in VTA-DA neurons. Left panel: typical current traces of sEPSCs before and after PTX (100 μM). Middle panel: typical time course of the frequency of sEPSCs before and after PTX (100 μM). Right panel: average frequency of sEPSCs before and after PTX (100 μM) (n = 6 cells from four rats, p = 0.29). Data are shown as the mean ±s.e.m. *p < 0.05.