Table 2.
The inhibition coefficient I 24 (%) for 24 h exposure and I 48 (%) for 48 h exposure for reflecting effect of benzonitrile pesticides on HEK293T cells for concentrations 25 mg/L, 50 mg/L, and 100 mg/L.
| Compounds |
I
24 (%) 25 mg/L |
I
48 (%) 25 mg/L |
I
24 (%) 50 mg/L |
I
48 (%) 50 mg/L |
I
24 (%) 100 mg/L |
I
48 (%) 100 mg/L |
|---|---|---|---|---|---|---|
| BRX | 34 ± 1 | 38 ± 2 | 52 ± 2 | 59 ± 2 | 52 ± 2 | 62 ± 2 |
| CHX | 68 ± 2 | 70 ± 1 | 70 ± 3 | 83 ± 3 | 70 ± 1 | 82 ± 4 |
| IOX | 48 ± 1 | 54 ± 2 | 59 ± 2 | 62 ± 3 | 59 ± 2 | 75 ± 3 |
| DCB | ND | ND | ND∗ | ND∗ | ND∗ | ND∗ |
BRX: 3,5-dibromo-4-hydroxybenzonitrile, CHX: 3,5-dichloro-4-hydroxybenzonitrile, IOX: 3,5-diiodo-4-hydroxybenzonitrile, and DCB: 2,6-dichlorobenzonitrile; ND: cytotoxicity not observed; ∗: the solubility of DCB in water is around 20 mg/L; therefore the inhibitions at concentrations 50 and 100 mg/L are only indicative; ±: standard deviation of 3 parallels.