Scheme 1. Synthesis of Chiral Synthon (R,R)-9.
Reagents and conditions: (a) CBr4, PPh3; (b) nBuLi, THF, then paraformaldehyde; (c) H2, quinoline, Lindlar catalyst, EtOAc; (d) Charette cyclopropanation, Et2Zn/CH2I2, dichloromethane, −20–0 °C.
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