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. 2015 Jul 10;6(8):936–941. doi: 10.1021/acsmedchemlett.5b00207

Scheme 3. Synthesis of Acetamide Analogue 32.

Scheme 3

Reagents and conditions: (a) 4 N HCl in dioxane; (b) 2-chloro-5-methoxymethylpyrimidine, Cs2CO3, DMSO, 60 °C, 76%; (c) NaH, 4-bromo-1-(bromomethyl)-2-fluorobenzene, DMF, 96%.; (d) BrZnCH2COOtBu, Pd2(dba)3, X-Phos, THF, 60 °C, 98%; (e) TFA, dichloromethane, 100%; (f) morpholine, HOBT, EDC, diisopropylethylamine, dichloromethane, 69%.