. 2015 Jul 10;6(8):936–941. doi: 10.1021/acsmedchemlett.5b00207

Table 2. Plasma Pharmacokinetic Profile of Compound 28^a.

species	Plasma Cl (mL/min/kg)	Vd (L/kg)	t_1/2 (h)	F (%)
rat^b	41	2.2	1.0	27
dog^c	6.0	6.5	17	60
monkey^d	16	2.0	2.3	5

PPB for 28 (f_u): r 4.1%, d 5.5%, rh 3.2, h 4.9%.

Rat Wistar Han: Cl_int = 1000 mL/min/kg; Vd_u = 54 L/kg.

Dog Beagle.

Rhesus monkey.

Table 2. Plasma Pharmacokinetic Profile of Compound 28a.