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. 2015 Jul 13;6(8):902–907. doi: 10.1021/acsmedchemlett.5b00170

Table 4. IC50 Values and EC50 Values of Representative Transrepression-Selective LXR Modulators.

    LXRs transactivation
  LXRs transrepression agonistic activity EC50 (μM)
 antagonistic activity IC50 (μM)
compound inhibition of IL-6 level IC50 (μM) LXRα LXRβ LXRα LXRβ
3 26 ± 17 0.21 ± 0.10 0.066 ± 0.013 N.T.b N.T.b
6 1.7 ± 1.6 N.A.a N.A.a 4.1 ± 0.045c 11 ± 0.43c
17l 1.5 ± 0.8 N.A.a N.A.a 3.3 ± 1.8 4.3 ± 0.46
a

No activity at 30 μM.

b

Not tested.

c

Data taken from ref (24).