Figure 2.

Heatmap of cell line sensitivity. (a) Heatmap of the z-scores of the log₁₀(EC₅₀) value of each compound across all cell lines. Red indicates sensitivity, while blue indicates resistance. Circles indicate neurosphere-grown cell lines and triangles indicate laminin-grown lines. (b) Each box in the heatmap is representative of the z-score of an EC₅₀ value, which has been generated from a 17-point dose–response curve. (c) The associated target of inhibition for each compound. Fourteen compounds that were not lethal to any cell lines, noted at the bottom of the list, were not included in the heatmap because a z-score could not be calculated.