Table 4. Pharmacokinetic Profile of BMS-911543.
| PK | mousea | ratb | dogc | cynod |
|---|---|---|---|---|
| CL (mL/min/kg) | 0.55 | 0.7 | 6.5 | 5.3 |
| Vss (L/kg) | 0.26 | 0.3 | 1.6 | 1.1 |
| T1/2 (h) | 5.1 | 5 | 2.2 | 2.4 |
| F (%) | 100 | 100 | 82 | 53 |
Mice were dosed 2.0 mg/kg IV and 10.0 mg/kg PO.
Rats were dosed 1.0 mg/kg IV and 1.0 mg/kg PO.
Dogs were dosed 0.2 mg/kg IV and 0.2 mg/kg PO.
Cyno were dosed 1.0 mg/kg IV and 1.0 mg/kg PO.