. 2015 Jun 29;6(8):913–918. doi: 10.1021/acsmedchemlett.5b00174

Table 2. Structure–Activity Relationships of Naphthyridine MAP4K4 Inhibitors (10–14)^a.

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See Table 1 for details.

Compounds were incubated with MDCK cells at 10 μM test concentration over 60 min. ER is efflux ratio, which is determined by rate of apical–basolateral/basolateral–apical flux.

Table 2. Structure–Activity Relationships of Naphthyridine MAP4K4 Inhibitors (10–14)a.

Table 2. Structure–Activity Relationships of Naphthyridine MAP4K4 Inhibitors (10–14)^a.