TABLE 5.
Summary of meropenem maintenance dosing recommendations based on the results of the present study
| PD target | Pathogen MIC (mg/liter) | Dose recommendation |
|---|---|---|
| 40% of the ƒuT>MIC | ≤4 | 500 mg q8h as a 30 min-bolus for all urine outputs |
| 100% of the ƒuT>MIC | ≤2 | 500 mg q8h as a 30-min bolus for oligoanuria, 500 mg q8h as a 3-h infusion for preserved diuresis |
| 2–4 | 500 mg q6h as a 30-min bolus for oligoanuria, 500 mg q6h as a 3-h infusion for preserved diuresis | |
| Cmin/MIC = 5 | ≤1 | 1,000 mg q8h as a 3-h infusion for all urine outputs |