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. 2015 Aug 14;59(9):5520–5528. doi: 10.1128/AAC.00712-15

TABLE 5.

Summary of meropenem maintenance dosing recommendations based on the results of the present study

PD target Pathogen MIC (mg/liter) Dose recommendation
40% of the ƒuT>MIC ≤4 500 mg q8h as a 30 min-bolus for all urine outputs
100% of the ƒuT>MIC ≤2 500 mg q8h as a 30-min bolus for oligoanuria, 500 mg q8h as a 3-h infusion for preserved diuresis
2–4 500 mg q6h as a 30-min bolus for oligoanuria, 500 mg q6h as a 3-h infusion for preserved diuresis
Cmin/MIC = 5 ≤1 1,000 mg q8h as a 3-h infusion for all urine outputs