TABLE 5.
Characteristics of mutations detected in rifampin-resistant mutants D1, D2, D3, and D6
| Type of mutation | Intragenic | Intergenic |
|---|---|---|
| Single base substitution (n = 19) | 16 | 3 |
| Transitions (n = 6) | 1 | 1 |
| A:T→G:C | ||
| G:C→A:T | 4 | 0 |
| A:T→C:G | 1 | 0 |
| G:C→T:A | 5 | 2 |
| G:C→C:G | 0 | 0 |
| A:T sites (n = 8) | 7 | 1 |
| G:C sites (n = 11) | 9 | 2 |
| Consequence | ||
| Synonymous | 2 | NAb |
| Missense | 14a | NAb |
| Nonsense | 0 | NAb |
| Insertion and deletion (n = 1) | 1 | 0 |
| Deletions (n = 0) | ||
| A or T | 0 | 0 |
| G or C | 0 | 0 |
| Insertions (n = 1) | ||
| A or T | 1 | 0 |
| G or C | 0 | 0 |
| Total (n = 20) | 17 | 3 |
a
NA, not applicable.
b
Including mutations leading to amino acid substitutions P27S, Q473K, Q473K, and Q473L in RpoB of mutants D1, D2, D3, and D6, respectively.