TABLE 3.

Analysis of embB mutations in ethambutol-resistant, ethambutol-sensitive, and pansensitive Mycobacterium isolates

Groupa	Codon	Nucleotide	Polymorphism	aa change	Frequency
					No. of isolates	%
EMBr	306	916	ATG→GTG	M→V	8	13
		918	ATG→ATC	M→V	5	20
			ATG→ATA	M→I	5
			ATG→ATT	M→I	2
	328	983	GAT→GGT	D→G	2	3
	330	988	TTC→CTC	F→L	1	2
Isolates without mutations					38	62
Total					61	100
EMBs	306	918	ATG→ATA	M→I	1	2
	320	960	TTC→TTG	F→L	7	14
	326	977	Deletion of base C	Frameshift	3	6
	328	983	GAT→GGT	D→G	1	2
Isolates without mutations					37	76
Total					49	100
Ps	306	918	ATG→ATA	M→I	1	2
Isolates without mutations					64	98
Total					65	100

^aEMB^r, ethambutol resistant; EMB^s, ethambutol sensitive; P^s, pansensitive.