TABLE 5.

Bivariate analysis of mutations at embB 306 and phenotypic drug resistance in M. tuberculosis isolates

Drug resistancea	Isolates in embB 306 group				Odds ratiob	95% confidence interval	P value
	Mutant (n = 22)		Wild type (n = 153)
	No.	%	No.	%
None	1	5	64	42	0.06	0.0–0.5	<0.01c
EMB	20	91	41	27	27.3	6.1–122.0	<0.01d
INH	21	95	69	45	25.6	3.4–194.9	<0.01c
RIF	19	86	56	37	11	3.1–38.7	<0.01c
PZA	9	41	34	22	2.4	1.0–6.2	0.06d
STR	15	68	54	35	3.9	1.5–10.2	<0.01d
MDR (INH+RIF)	19	86	53	35	11.9	3.4–42.2	<0.01c
EMB+INH+RIF	18	82	31	20	17.7	5.6–56.1	<0.01c

^aEMB, ethambutol; INH, isoniazid; RIF, rifampin; PZA, pyrazinamide; STR, streptomycin; multidrug resistance (MDR).

^bThe OR was calculated by associating the risk of having determined drug resistance with the presence of embB 306 mutation. The opposite event of each variable was used like a comparison group (no. resistant/resistant; EMB resistant/EMB sensitive; INH resistant/INH sensitive; RIF resistant/RIF sensitive; PZA resistant/PZA sensitive; STR resistant/STR sensitive; MDR (INH+RIF) resistant/MDR sensitive; EMB+INH+RIF resistant/EMB+INH+RIF sensitive).

^cBy Fisher's exact test. P values of <0.05 are significant.

^dBy chi-square test. P values of <0.05 are significant.