TABLE 1.
Characteristics of MSSA BSI cohort according to treatment and treatment outcome
| Characteristica | Patients treated with: |
P value | Observed failure | Univariate OR for failure | P value | |
|---|---|---|---|---|---|---|
| Cefazolin | Oxacillin | |||||
| Age (mean [SD]) (yr) | 53.3 (16.7) | 53.6 (18.4) | 0.91 | 52.9 (17.1) | 0.99 | 0.91 |
| Admit wt (mean [SD]) (kg) | 79.5 (22.4) | 81.5 (25.3) | 0.61 | 76.9 (21.1) | 0.99 | 0.60 |
| Male (no. [%]) | 60 (58.3) | 36 (62.1) | 0.64 | 9 (69.2) | 0.63 | 0.56 |
| Race (no. [%]) | 0.019 | 1.32 | 0.31 | |||
| African-American (n = 60) | 46 (44.7) | 14 (24.1) | 0.01 | 7 (53.9) | 2.09 | 0.20 |
| Caucasian (n = 70) | 37 (35.9) | 33 (56.9) | 0.01 | 3 (23.1) | 0.36 | 0.15 |
| Hispanic (n = 24) | 14 (13.6) | 10 (17.2) | 0.53 | 3 (23.1) | 1.81 | 0.41 |
| Other (n = 7) | 6 (5.8) | 1 (1.7) | 0.42 | 0 (0) | >0.99 | |
| m-APACHE score day 0 (mean [SD]) | 13 (6.3) | 10.3 (5.8) | 0.009 | 11.9 (5) | 0.99 | 0.95 |
| Baseline serum creatinine (median [IQR]) | 1.2 (0.8–7.13) | 1.05 (0.81–1.92) | 0.19 | 0.97 (0.74–2.36) | 0.88 | 0.29 |
| ICU admission (no. [%]) | 43 (41.8) | 19 (32.8) | 0.26 | 9 (69.2) | 4.03 | 0.03 |
| Renal dysfunction (no. [%]) | 51 (49.5) | 17 (29.3) | 0.013 | 5 (38.5) | 0.84 | 0.77 |
| History of orthopedic procedure (no. [%]) | 25 (24.3) | 7 (12.1) | 0.06 | 3 (23.1) | 1.23 | 0.72 |
| History of prosthetic device (no. [%]) | 22 (21.4) | 5 (8.6) | 0.048 | 3 (23.1) | 1.55 | 0.46 |
| Source of infection (no. [%]) | ||||||
| Skin/wound | 15 (14.6) | 13 (22.4) | 0.21 | 1 (7.7) | 0.37 | 0.47 |
| Urinary | 2 (1.9) | 1 (1.7) | >0.99 | 0 (0) | >0.99 | |
| Cerebrospinal fluid | 0 (0) | 1 (1.7) | 0.36 | 1 (7.7) | 0.08 | |
| Bone/joint | 21 (20.4) | 8 (13.8) | 0.30 | 4 (30.8) | 2.19 | 0.25 |
| Central line/dialysis access | 47 (45.6) | 14 (24.1) | 0.007 | 5 (38.5) | 1.03 | >0.99 |
| Respiratory | 2 (1.9) | 1 (1.7) | >0.99 | 0 (0) | >0.99 | |
| Source control (no. [%]) | 79 (76.7) | 30 (51.7) | 0.001 | 10 (76.9) | 1.65 | 0.55 |
| Metastatic disease (no. [%]) | 30 (29.1) | 11 (19.0) | 0.16 | 7 (53.9) | 3.91 | 0.014 |
| Deep-seated infection (no. [%])b | 32 (31.1) | 20 (34.5) | 0.66 | 9 (69.2) | 5.49 | 0.005 |
| Endocarditis (n = 29) | 17 (53.1) | 12 (60.0) | 0.63 | 6 (66.7) | 1.74 | 0.47 |
| Other deep-seated infections (n = 23) | 15 (46.9) | 8 (40.0) | 3 (33.3) | |||
| Total (no. [%]) | 103 (64) | 58 (36) | 13 (8.1) | |||
a
m-APACHE, modified APACHE II score; IQR, interquartile range; ICU, intensive care unit.
b
Deep-seated infection was considered infectious endocarditis or any of the following: bone and joint, deep-seated abscesses, osteomyelitis, pneumonia, or unresolved vascular graft infections.