. 2015 Aug 14;59(9):5814–5818. doi: 10.1128/AAC.00534-15

TABLE 1.

Antiviral activities of SG85 and rupintrivir against 14 RV and 4 enteroviruses in virus-cell-based assays

Virus strain	Median EC₅₀ (μM) ± MAD^a
Virus strain	SG85	Rupintrivir
RV-A
RV02	0.14 ± 0.03^a	0.010 ± 0.006^a
RV09	0.032 ± 0.008^a	0.011 ± 0.001^a
RV15	0.031 ± 0.004^a	0.013 ± 0.001^a
RV29	0.04 ± 0.03^a	0.008 ± 0.002^a
RV41	0.038 ± 0.007^a	0.0036 ± 0.0008^a
RV59	0.04 ± 0.02^a	0.0102 ± 0.0001^a
RV63	0.01 ± 0.01^a	0.0106 ± 0.0009^a
RV85	0.15 ± 0.02^a	0.015 ± 0.008^a
RV89	0.05 ± 0.06^a	0.0040 ± 0.0002^a
RV-B
RV14	0.055 ± 0.008^a	0.018 ± 0.002^a
RV42	0.02 ± 0.02^a	0.0026 ± 0.0008^a
RV70	0.05 ± 0.05^a	0.0111 ± 0.0001^a
RV72	0.008 ± 0.005^a	0.00356 ± 0.0001^a
RV86	0.02 ± 0.02^a	0.0096 ± 0.0008^a
EV-A EV71	0.10 ± 0.04^a	0.004 ± 0.002^a
EV-B CVB3	0.5 ± 0.1^a	0.25 ± 0.04^a
EV-B ECHO11	33 ± 7^a	2.8 ± 0.7^a
EV-C PV1	39 ± 18	8.2 ± 2.7^a

Antiviral activity was determined in a CPE reduction assay with a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium readout. The results shown are from dose-response curves set up from four or more experiments of which at least two were independent. MAD, median absolute deviation.

One hundred percent inhibition of a virus-induced CPE can be achieved with this compound (as determined by microscopic inspection).