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Results of the screening of the Spectrum Collection (2,400 compounds). Reactions (25-μl mixtures) were performed in 384-well plates and included 0.5 mg/ml beads, 0.2% (wt/vol) Brij 58, 0.3 μM bhCA-2, and 0.1 μM [3H]PF74. The screening scored 43 hits that produced an assay signal of <3 standard deviations from the average signal from all the screened compounds.
