TABLE 1.
Pharmacodynamic parameters for fosfomycin obtained from the hollow fiber infection model
| PD parameter | PD value for simulated human dosage (total dose/day) from: |
|||||
|---|---|---|---|---|---|---|
| Range-finding study |
Fractionation study |
|||||
| 4 g/q8h (12 g) | 8 g/q8h (24 g) | 12 g/q8h (36 g) | 6 g/q12h (12 g) | 12 g/q24h (12 g)a | 12 g/q24h (12 g)b | |
| fAUC0–24 (mean) | 1,744.94 | 3,136.03 | 4,287.82 | 2,121.83 | 2,366.83 | 2,404.61 |
| fAUC0–24/MIC (MIC = 1 mg/liter)c | 1,744.94 | 3,136.03 | 4,287.82 | 2,121.83 | 2,366.83 | 2,404.61 |
| fAUC0–24/MIC (MIC = 64 mg/liter)d | 27.26 | 49 | 67 | 33.15 | 36.98 | 37.57 |
a
Data are for fosfomycin delivered in 1-h infusion.
b
Data are for fosfomycin delivered via continuous infusion for 24 h.
c
Data are for strain Ec46, for which the MIC is 1 mg/liter.
d
Data are for strain Ec42444, for which the MIC is 64 mg/liter.