TABLE 2.
Parameter estimates from the mathematical model used for range-finding studies for suppression of emergence of fosfomycin-resistant mutants
| Parametera | Dosage (total dose/day) |
||||
|---|---|---|---|---|---|
| 4 g/q8h (12 g) | 5 g/q8h (15 g) | 6 g/q8h (18 g) | 8 g/q8h (24 g) | 24 g/q24h (24 g) | |
| V (liters) | 36.01 | 37.57 | 37.82 | 39.20 | 39.36 |
| SCL (liters/h) | 5.54 | 5.47 | 6.16 | 6.11 | 6.07 |
| KgMAX-S (CFU/ml/h) | 5 | 5 | 4.43 | 3.46 | 2.7 |
| KgMAX-R (CFU/ml/h) | 1.17 | 1.161 | 1.15 | 2.04 | 0.7 |
| KkMAX-S (CFU/ml/h) | 7.21 | 7.14 | 8.3 | 3.81 | 4.31 |
| KkMAX-R (CFU/ml/h) | 0.97 | 0.97 | 0.94 | 3.38 | 1.38 |
| C50k-S (mg/liter) | 41.09 | 51.02 | 56.1 | 1.01 | 46.01 |
| C50k-R (mg/liter) | 5 | 5 | 5.02 | 5.54 | 41.94 |
| Hk-S | 12.43 | 13.36 | 1.33 | 13.4 | 5.07 |
| Hk-R | 17.9 | 17.83 | 19.04 | 17.61 | 0.5 |
| POPMAX (CFU/ml) | 1.72 × 1010 | 7.94 ×109 | 1.43 ×1010 | 3 ×109 | 3 ×1010 |
| INITCOND_2 (CFU/ml) | 5.76 ×106 | 5.54 ×106 | 1 ×106 | 1 ×106 | 1.48 ×106 |
| INITCOND_3 (CFU/ml) | 1.69 ×102 | 1.69 ×102 | 1.69 ×102 | 1.73 ×102 | 4.71 ×102 |
a
SCL is the fosfomycin clearance. INITCOND_2 and INITCOND_3 are the initial conditions for the total and resistant bacterial populations, respectively. Other parameter abbreviations can be found in the text.