TABLE 3.
Parameter estimates from the mathematical model from the drug combination study
| Parametera | Mean | Median | 95% CI |
|---|---|---|---|
| V1 (liters) | 11.71 | 12.56 | 10.0–12.60 |
| CL1 (liters/h) | 6.21 | 5.98 | 4.84–7.80 |
| V2 (liters) | 29.12 | 28.22 | 25.91–33.09 |
| CL2 (liters/h) | 6.59 | 6.32 | 4.48–8.94 |
| POPMAX (CFU/ml) | 1 × 1010 | 1 × 1010 | 1 × 1010–1.1 × 1010 |
| Kg-S (CFU/ml/h) | 1.59 | 1.50 | 1.27–2.00 |
| Kk-S (CFU/ml/h) | 2.43 | 2.21 | 2.08–3.00 |
| E50_1S (mg/liter) | 8.33 | 8.32 | 7.30–9.35 |
| E50_2S (mg/liter) | 13.51 | 14.84 | 10.00–15.75 |
| α_S | 4.78 | 4.88 | 0.878–8.56 |
| KgR-2 (CFU/ml/h) | 0.70 | 0.20 | 0.101–1.79 |
| KkR-2 (CFU/ml/h) | 2.52 | 2.97 | 1.23–3.38 |
| E50-2R2 (mg/liter) | 34.33 | 28.22 | 22.13–52.52 |
| α_R2 | 0.41 | 0.48 | −4.84–5.49 |
| INIT_3 (CFU/ml) | 1 × 1010 | 1 × 1010 | 1 × 1010–1.1 × 1010 |
| H1-S | 12.19 | 11.95 | 10.71–13.89 |
| H2-S | 2.25 | 1.58 | 1.12–4.00 |
| H2-R2 | 4.96 | 5.74 | 3.30–5.82 |
| TLAG3 (h) | 42.70 | 43.04 | 32.34–52.78 |
a
For parameters that include a subscript numeral (1 or 2), 1 denotes a meropenem parameter and 2 denotes a fosfomycin parameter. INIT_3 is the initial condition for the total bacterial population. TLAG3 is the lag time for the fosfomycin-resistant mutants' regrowth. E50 is the half-maximal effective concentration. α_S and α_R are the interaction parameters between the antimicrobials for the susceptible and resistant populations, respectively.