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. 2015 Aug 14;59(9):5819–5823. doi: 10.1128/AAC.00273-15

FIG 2.

FIG 2

Histopathological and immunohistochemical findings for VL-affected organs. Histopathological (H&E staining) (upper) and immunohistochemical (CD3 staining) (lower) evaluations of spleen (A) and liver (B) of C57BL/6 mice sequentially treated with liposomal amphotericin B and LEISHDNAVAX were performed. f, follicles (white pulp); g, granulomas. Arrows, constituent CD3+ cells. Arrowheads, CD3+ cells within granulomas. Images are representative of 5 mice/group from one experiment. Data indicate the percent area of immunohistochemical (IHC) positivity (CD3 staining) for the number of animals indicated (n). Values are group means ± standard deviations. A, administration of liposomal amphotericin B; A + V(100), coadministration of liposomal amphotericin B and LEISHDNAVAX at 100 μg of total DNA. Magnification, ×200.