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. 2015 Aug 14;59(9):5631–5640. doi: 10.1128/AAC.00850-15

TABLE 2.

Susceptibilities of fungal pathogens, bacteria, and cultured mammalian cells to CANBEF-13, -14, and -24

Strain CANBEF-13
CANBEF-14
CANBEF-24
MIC (μM) MEC (μM) MIC (μM) MEC (μM) MIC (μM) MEC (μM)
Fungal pathogenic isolates
    Candida albicans
        ATCC 2901 12.50 12.50 6.25 12.50 6.25
        ATCC 90028 12.50 12.50 6.25 12.50 6.25
        18804 12.50 12.50 6.25 12.50 6.25
    Candida rugosa 3929 6.25 3.13 3.13 1.56 3.13 1.56
    Candida parapsilosis ATCC 22019 12.50 12.50 6.25 12.50 6.25
    Candida tropicalis ATCC 20336 12.50 6.25 3.13 6.25 3.13
    Candida glabrata 59343 12.50 6.25 3.13 6.25 3.13
    Candida krusei ATCC 6258 12.50 3.13 1.56 3.13 1.56
    Mucor racemosus
        3465 ≤12.50 ≤12.50 6.25 6.25 6.25 6.25
        3484 ≤50.00 ≤50.00 ≤50.00 25.00 ≤50.00 25.00
        167 ≤50.00 25.00 6.25 3.13 6.25 3.13
    Rhizopus arrhizus 156 ≤50.00 ≤50.00 ≤50.00 25.00 ≤50.00 25.00
    Fusarium oxysporum 600711 ≤50.00 25.00 25.00 3.13 25.00 3.13
    Fusarium solani
        603251 ≤25.00 12.50 25.00 3.13 25.00 3.13
        600679 ≤25.00 12.50 3.13 1.56 3.13 1.56
    Aspergillus fumigatus
        Af293 3.13 0.78 3.13 0.78 3.13 0.78
        ATCC 13073 ≤12.50 ≤12.50 6.25 3.13 6.25 3.13
    Aspergillus flavus
        Strain #1 ≤12.50 6.25 6.25 1.56 6.25 1.56
        Strain #2 ≤12.50 6.25 6.25 1.56 6.25 1.56
    Aspergillus niger
        Strain #1 ≤12.50 ≤12.50 6.25 1.56 6.25 1.56
        Strain #2 ≤12.50 ≤12.50 6.25 1.56 6.25 1.56
        Strain #3 ≤12.50 ≤12.50 3.13 1.56 3.13 1.56
    Saccharomyces cerevisiae
        A2 0.20 1.56 1.56
        BY4741 0.20 1.56 1.56
Bacterial species
    Escherichia coli ≤50.00 ≤50.00 ≤50.00
    Staphylococcus epidermidis ≤50.00 ≤50.00 ≤50.00
    Staphylococcus aureus 25.00 ≤50.00 25.00
    Bacillus cereus 6.25 25.00 12.50
Mammalian cell lines
    NIH 3T3 ≤50.00 ≤50.00 ≤50.00
    A549 ≤50.00 ≤50.00 ≤50.00