TABLE 6.
Activity of paritaprevir, ombitasvir, and dasabuvir against variants in GT1a H77 replicon
| NS3 |
NS5A |
NS5B |
|||
|---|---|---|---|---|---|
| Variant | Fold resistance to paritaprevir | Variant | Fold resistance to ombitasvir | Variant | Fold resistance to dasabuvir |
| V36A | 3 | M28T | 8,965 | C316Y | 1,472 |
| V36M | 2 | M28V | 58 | M414I | 8 |
| Y56H | 3 | Q30R | 800 | M414T | 32 |
| R155K | 37 | L31M | 2 | A553T | 152 |
| D168A | 50 | H58P | 0.5 | G554S | 198 |
| D168V | 96 | Y93N | 66,740 | S556G | 30 |
| D168Y | 219 | G558R | NDa | ||
| V36M + R155K | 79 | D559G | ND | ||
| Y56H + D168Y | 451 | ||||
a
ND, fold resistance could not be determined due to the low replication capacity of the variant.