TABLE 7.
Distribution of prevalent baseline variants by geographic region
| Target, GT | Variant | Phylogenetic cluster | %a |
|
|---|---|---|---|---|
| United States | European Union | |||
| NS3, GT1a | Q80K | Clade 1 (n = 140) | 67.4 (87/129) | 50 (5/10) |
| Clade 2 (n = 89) | 3.3 (2/61) | 0 (0/27) | ||
| Total | 46.8 (89/190) | 13.5 (5/37) | ||
| NS5A, GT1a | M28V | 7 (14/191) | 0 (0/42) | |
| NS5B, GT1a | S556G | Clade 1 | 2.9 (4/139) | 6.2 (1/16) |
| Clade 2 | 3.1 (2/65) | 2.8 (1/36) | ||
| Total | 2.9 (6/204) | 3.9 (2/52) | ||
| NS5A, GT1b | Y93H | 2.9 (2/68) | 8.2 (5/61) | |
| NS5B, GT1b | C316N | 4.6 (3/65) | 32 (19/59) | |
| S556G | 6.2 (4/65) | 25 (15/59) | ||
a
The percentage of patients within each geographic region with the variant. Values in parentheses represent the number of patients with the variant/number of available sequences in the geographic region for each target.