TABLE 2.

Noncompartmental pharmacokinetic parameter estimates of cefepime from 12 febrile neutropenic patients with hematological malignancies

Parametera	Mean	Median	IQRb
Vss (liters/kg)	33.4	34	24.8–42.7
CL (liters/h)	8.6	8.7	6.8–10.8
t1/2 (h)	2.7	2.5	2.4–3.0
MRT (h)	3.9	3.6	3.5–4.4
AUC0–inf (mg/liter · h)	269	232	186–294
kel (1/h)	0.3	0.3	0.2–0.3

^aV_ss, volume of distribution at steady state; CL, total clearance; t_1/2, half-life; MRT, mean residence time; AUC_0–inf, area under the concentration versus time curve from time zero to infinity; k_el, terminal elimination rate constant.

^bIQR, interquartile range.