TABLE 2.
Parametera | Valueb |
---|---|
2 mg/kg i.v. | |
∼t1/2 (h) | 11 (2) |
Vss (liters/kg) | 1.4 (0.2) |
5 mg/kg oral | |
Cmax (μg/ml) | 0.8 (0.2) |
AUC0−48 h (h · μmol/ml) | 33 (6) |
∼t1/2 (h) | >48c |
F (%) | 73 |
Plasma protein binding (%) | 97.2 (0.4) |
Liver microsomal stability (%) | 100d |
t1/2, half-life; Vss, volume of distribution at steady state.
All values are means (SD).
t1/2 values could not be accurately determined due to the lack of data at extended time periods.
All time points showed >92% remaining, with the average value being 98% remaining in comparison to the level seen at the zero time point.