TABLE 2.
In vivo and in vitro pharmacokinetic parameters for VT-1161 in the mouse
| Parametera | Valueb |
|---|---|
| 2 mg/kg i.v. | |
| ∼t1/2 (h) | 11 (2) |
| Vss (liters/kg) | 1.4 (0.2) |
| 5 mg/kg oral | |
| Cmax (μg/ml) | 0.8 (0.2) |
| AUC0−48 h (h · μmol/ml) | 33 (6) |
| ∼t1/2 (h) | >48c |
| F (%) | 73 |
| Plasma protein binding (%) | 97.2 (0.4) |
| Liver microsomal stability (%) | 100d |
a
t1/2, half-life; Vss, volume of distribution at steady state.
b
All values are means (SD).
c
t1/2 values could not be accurately determined due to the lack of data at extended time periods.
d
All time points showed >92% remaining, with the average value being 98% remaining in comparison to the level seen at the zero time point.